A TRUCK carrying flammable liquid became fully involved with fire on the Hume Freeway early last Friday morning at Chiltern.

A CFA spokesperson said 16 CFA units alongside FRV responded at around 3.44am, December 13.

"Units responded from Wangaratta, Chiltern, Barnawartha, Browns Plains, Wangaratta North, Rutherglen, Tarrawingee, Bowser, and Springhurst," she said.

"Crews discovered a truck fully involved in fire, including a trailer.

"The truck was carrying flammable liquid and the fire was spreading to nearby grass."

An advice warning was issued for the smoke in the area.

EPA and an excavator were called to the scene to assist with clean-up.

Incident was deemed under control at 5.33am.

All northbound lanes of the Hume Freeway were closed between Springhurst and Chiltern.

Motorists were diverted onto Rutherglen-Springhurst Road before taking the Murray Valley Highway, and returning to the Hume Freeway at Barnawartha North.

Detours added up to 15 minutes to the regular journeys on the freeway.

Due to the scale of the fire, an extensive clean-up of the site ensued, after which time crews assessed the road damage and the repairs required.

Real-time traffic conditions were available at traffic.transport.vic.gov.au.

Ambulance Victoria paramedics responded to the incident but emergency treatment of transport was not required.